Observe the possible mechanisims of sea buckthorn procyanidins(SBPC) Treat gastritis and study the relationship with apoptosis / 重庆医科大学学报

ABSTRACT

Objective:To observe the effects of sea buckthorn procyanidins(SBPC)on MK and platelet activating factor(PAF)in helicobacterpylori-associated gastritis and study the potentional mechanisim.Methods:80 cases were randomized into two groups.42 cases in the SBPC group which were given SBPC and 38 cases in the control group which were given three combined mecidine.TUNEL technique and immunohistochemistry were used to detect the apoptotic cells.Detection on Biospy Specimens of gastric mucosa was done.H.pylori was detected by urease test and Warthin-Starry method and To observe the effects of sea buckthorn procyanidins(SBPC)on the expressions of MK and platelet activating factor(PAF),which were observed by Immunohischemical and Western blotting method.All of the patients underwent gastroscopy at the 6th week.Results:The difference of apoptotic index between SBPC group and control group had great statistical significance,with the total efficience of SBPC higher than that of control group(P