Effect Of Chinese Herbal Medicine of Astringents on Hepatoma Hematogenous and Lymphatic Metastasis in Mice / 中药新药与临床药理

ABSTRACT

Objective To investigate the effect of Chinese herbal medicine of astringents on H22 ascitic type hepatoma haematogenous and lymphatic metastasis in mice.Methods In hematogenous metastasis experiment,the growth of lung metas- tasis and hemorheological indexes were observed in Kunming mice after intravenous injection of H22 ascitic type hepatoma into the caudal veins.In lymphatic metastasis experiment,hepatocarcinoma metastasis mice models were established by subcuta- neous injection of H22 hepatocareinoma cells into the right lower limb,and the inhibitory- rate of tumor weight,incidence of metastasis carcinoma in lung,metastasis of lymph nodes were observed.Results In hematogenous metastasis experiment, compared with the model group,the number of metastatic nodules in lung was decreased in Cortex Ailanthi group and Fructus Corni group,and Cortex Ailanthi improved the hemorheological indexes.In lymphatic metastasis experiment,compared with the control group,the number of metastatic nodules in lung was decreased and the inhibitory rate of tumor weight was increased in Fructus Mume group and Fructus Corni group.The metastases of lymph node were decreased in the three astringents groups. Conclusion Chinese herbal medicine of astringents has an inhibitory effect on the metastasis of hepatoma haematogenous and lymphatic metastasis.