An immunohistochemical study on the time-dependent expression of MIP-1?during healing of skin incised wound in mice / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-578655
ABSTRACT
Objective:
To explore the expression of MIP-1? during healing of skin incised wound and the applicability of time-dependent expressions of MIP-1? to determination of wound age.Methods:
An incised wound was made in the dorsal skin of mouse. Immunohistochemical and image-analysis techniques were employed in vital skin wounds 1h~14d after incision and postmortem incision 0.5~6h after death, and the non-incised mouse skin was used as contro1.Results:
In the vital skin incisions,expression of MIP-1? began at 6h after incision,which increased subsequently,and peaked at 3d.The quantity of MIP-1?expression decreased and minimized in the specimens aged 14 days. In the non-wounded groups and postmortem incision groups MIP-1? was only detected as weak expression in the epidermic cells,sweat gland cells and endothelial cells.Conclusion:
The time-dependent expression of MIP-1?during healing of skin incised wound may be used as a useful reference marker.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
2007
Type:
Article
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