Investigation of the stability of adriamycin liposome by TLC / 重庆医科大学学报

ABSTRACT

Objective:To investigate the usability of TLC as a evaluating method for adriamycin liposome stability by separating its composition and degradation products with TLC and improve this method. Methods:The plates were developed twice with four development systems,visualized by 4-methoxybenzaldehyde. Results:It was better to separate EPC,cholesterol and their degradation products by using chloroform-methanol-water-ammonia(65∶35∶2.5∶2.5) as the mobile phase. Conclusion:TLC could be used for the quality control of the adriamycin liposome due to its simple operation and high reproducibility.