Oxygen free radical damage and it's effect on ultrastructure result in erection dysfunction on diabetes mellitus rat / 重庆医科大学学报

ABSTRACT

Objective:To observe the change of the oxygen free radical and antioxygen level that existed in cavernous body of penis of diabetus mellitus(DM) rat with erection dysfunction(ED),and observe the morphology change on the electron microscope to probe into the nosogenesis of DMED. Methods:To make the DMED model on rat by streptozotocin,breed for 12 weeks after it,then to determin the indexes about oxygen free radical and antioxygen level and ultrastructure of cavernous smooth muscle after anesthetize. Results:The level of oxygen free radical increased and antioxygen decreased,the blood capillary thrombogenesised,the chondriosome swelled and distend,the desmocyte activated,the nerve fiber medullary sheath degenerated,all those were observed in the DMED group,and had significant different with control group. Conclusion:The change of ultrastructure occurred in DMED rat induced by the oxygen free radical damage and decrease of antioxygen level,it has associativity with the aggravation of smooth muscle endodermis,the blood vessel endothelium,the nerve fiber and the chondriosome,it's ONE OF the nosogenesis of DMED.And it suggested to use oxygen free radical scavenger may be relieve the change of ultrastructure and ED,it may be supply anthoer therapy pathway for DMED.