Electrophysiological effects of resveratrol on autorhythmicity organization in left ventricular outflow tract of guinea pig / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-578764
ABSTRACT
AIM:
To study the electrophysiological effects of resveratrol from grape and polygonum cuspidate on autorhythmicity organization in left ventricular outflow tract of guinea pig and its intracellular mechanism.METHODS:
In choosing guinea pig weighing 250~300 g,the action potential,including its MDP(maximal diastolic potential),APA(amplitude of AP),Vmax(maximal rate of zero phase depolarization),VDD[velocity of diastolic(phase 4)depolarization],RPF(rate of pacemaker firing)and APD_ 50,APD_ 90(the duration of 50% and 90% repolarization of action potential),were observed and recorded by means of the intracellular microelectrode technique.RESULTS:
(1)Resveratrol could reduce the electric activity of left ventricular outflow tract.Resveratrol(30、60、120 ?mol/L)not only significantly decreased APA and Vmax,but also decreased VDD and RPF respectivily(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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