Transdermal absorption effect of ?-cyclodextrin inclusion on lilac-cassiabark Gel / 中成药

ABSTRACT

AIM:To investigate the effect of ?-cyclodextrin inclusion on transdermal absorption of volatile oil in lilac-cassiabark Gel. METHODS: The release test of two kinds of lilac-cassiabark Gel(gel A without ?-cyclodextrin inclusion and gel B with ?-cyclodextrin inclusion) was assayed with Franz diffusion cell with the help of the cumulative amount of eugenol in unit area in vitro. RESULTS: The percutaneous absorption process of eugenol in two kinds of gels were conformed to zero-order releasing model,and the transdermal rates were 16.212?4.128 and 11.344?1.929 ?g/(cm~2?h) respectively.Compared with gel A,the transdermal rate of eugenol was slower in gel B(P