Relation between the expression of RAR?,RAR? and endometrial carcinoma / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-578894
ABSTRACT
Objective:
To evaluate the role of the retinoic acid receptor ?(RAR?),retinoic acid receptor ?(RAR?) in the devel-opment and prognosis of the endometrial carcinoma by detecting the expression of these receptors.Methods:
48 cases of paraffin-embedded tissues were selected, including 42 cases of adenocarcinoma and 6 cases of adeno-squamous carcinoma of endometrium. Immunohistochemistry was used to detect the level of RAR? and RAR?. The relation between the expression of these receptors and the clinical pathological parameters was evaluated.Results:
The positive expression ratios of the RAR? and RAR? were 47.92%(23/48)and 25.00%(12/48),respectively. The level of RAR? was significantly higher than that of RAR?(P0.05). The level of the RAR? decreased with the increasing of the malignancy extent of the endome-trial adenocarcinoma(P0.05)respectively.Conclusion:
There is close relation between the ex-pression of the RAR? and the development of the endometrial carcinoma. The defect of the RAR? and the high expression of the RAR? indicates a bad prognosis of the endometrial carcinoma. Detection of these two is benefited receptors together for us to estimate the prognosis of the carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS