Experimental Study of Cichorii Extract Intervening Uric Acid and Lipid Metabolic Disorder of Quail Caused by High-purine Diet / 中国中医药信息杂志

ABSTRACT

Objective To observe the influence of Cichorii extract on uric acid and lipid metabolic disorder and discuss the mechanism. Methods Quails were divided randomly into 5 groups by weightnormal group,model group,positive control group and Cichorii extract high and low dosage group,15 quails in each group. The normal group was fed with the common feeder,and the other groups were fed with the yeast powder. Positive control group was given Benzbromarone 20 mg/(kg?d). Cichorii extract high and low dosage group were given Cichorii extract 15,10 g/(kg?d) respectively. Normal and model group were given distilled water. UA,TG,FFA,TC,HDL,LDL level and XOD,ADA,GD activity related to uric acid metabolism were determined after 7 days. Results Compared with normal group,UA,TG,FFA of model group was significantly higher and HDL was significantly lower. Compared with model,Cichorii extract decreased UA,TG,FFA significantly. GD activity in model group increased significantly. Cichorii extract decreased GD activity. There was no significant variance of XOD and ADA activity in each group. Conclusion Cichorii extract had obvious effect in adjusting uric acid and lipid metabolic disorder. The possible mechanism was by decreasing GD activity and decreasing UA,FFA level.