Protective Effects of Hypericum attenuatum Choisy. Extract on Myocardial Ischemia in Mice / 中国中医药信息杂志

ABSTRACT

Objective To investigate the protective effects of Hypericum attenuatum Choisy. extract on experimental myocardial ischemia injury in mice. Methods The myocardial ischemia injury model was induced by isoproterenol in mice. The survival time of mice,the activities of LDH and CK in serum,the activity of SOD and level of MDA in myocardium were all measured. Results Compared with model group,Hypericum attenuatum Choisy. extract can prolong the survival time of mice after injured by isoproterenol in the close normobaric hypoxia,and decrease the activities of LDH and CK in serum. It can also increase the activity of SOD and decrease the level of MDA in myocardium. Conclusion Hypericum attenuatum Choisy. extract has protective effects on myocardial ischemia induced by isoproterenol in mice.