The Effect of Glutathione on High Dose Cisplatin-Induced Cellular Toxicity in Non-small Cell Lung Cancer Cell Lines / 결핵
Tuberculosis and Respiratory Diseases
;
: 463-474, 2002.
Article
in Korean
| WPRIM
| ID: wpr-57934
ABSTRACT
BACKGROUND:
This study was designed to examine how glutathione, one of the nucleophilic sulfur compounds, effects the cisplatin cellular toxicity in the non-small cell lung cancer cell lines and normal lung epithel ial cell line.METHODS:
Three cultured cell lines, the lung adenocarcinoma cell(NCL-H23), the lung squamous carcinoma cell (SK-MES-1) and the normal lung epithelial cell(L-132) line were exposed to various concentrations of cisplation with or without glutathione. The relative viability was estimated as a means of measuring the cisplatin cellular toxicity using the MTT method.RESULTS:
In NCL-23, the response to cisplatin was sensitive but glutathione markedly increased the relative survival of the tumor cells by removing the antitumor effect of cisplatin. In both SK-MES-1 and L-132, the responses to cisplatin were less sensitive, and the chemoprotective effect of glutathione compared to an equal cisplatin dose was signigicantly higher in L-132 than in SK-MES-1(p<0.05).CONCLUSION:
The protective effects of glutathione on cisplatin-induced cellular toxicity is more signigicant in normal lung epithelial cells than in squamous carcinoma cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sulfur Compounds
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Cell Line
/
Cells, Cultured
/
Cisplatin
/
Carcinoma, Non-Small-Cell Lung
/
Epithelial Cells
/
Glutathione
/
Lung
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2002
Type:
Article
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