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Absorption mechanism of aesculin across Caco-2 monolayer mode / 中成药
Chinese Traditional Patent Medicine ; (12)1992.
Article in Chinese | WPRIM | ID: wpr-579747
ABSTRACT

AIM:

To research the absorption mechanism of aesculin across Caco-2 monolayer model.

METHODS:

The Caco-2 cell monolayers drug transport model was assigned to study the double transport mechanism of aesculin to explore the absorption of aesculin according as time and drug concentration determined through HPLC and the P_ app was calcalated.

RESULTS:

In the Caco-2 monolayer model,the transport of aesculin form Apical to Basolateral was similar to the transport form basolateral to apical.

CONCLUSION:

The main mechanism of the aesculin intestinal absorption in the Caco-2 monolayer model is passive transference.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional Patent Medicine Year: 1992 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional Patent Medicine Year: 1992 Type: Article