Expression and implication of apoptosis related gene bcl-2,bad in human breast cancer / 重庆医科大学学报

ABSTRACT

Objective:To evaluate the expression and significance of Bcl-2 ,Bad gene and its relationship with prognosis of breast cancer.Methods:Immunohistochemical technique was used to detect the expression of Bcl-2 ,Bad gene in 10 cases of normal breast tissue,10 breast fibroadenoma tissue,40 young human breast carcinoma tissue and 40 old human breast carcinoma tissue.The expression of ER and PR in 80 cases of human breast carcinoma tissue were also detected.Results:The expression of bcl-2,bad gene decreased in the development of breast cancer(P0.05).Conclusion:The expression of bcl-2 and bad can be used as predicted factors of breast cancer.Detection of the expression level of the bcl-2 protein,in particular the combined detection of the expressions of bcl-2 and bad as well as ER and PR is helpful in forecasting the prognosis of breast carcinoma and instructing the treatment.