Protective Effect of Weishu Powder on Hepatic Injury Induced by Pentachloronitrobenzene / 广州中医药大学学报

ABSTRACT

Objective To observe the protective effect of Weishu Powder(WP) on hepatic injury induced by pentachloronitrobenzene(PCNB).Methods SD rats were randomized into 4 groups normal group,model group,high-dosage WP group(in the dose of 2.50 g?kg-1 ?d-1) and low-dosage WP group(in the dose of 1.25 g?kg-1 ?d-1).Except the normal group,the other three groups received gastric gavage of PCNB 400 mg?kg-1 ?d-1 for 15 continuous days.After treatment,hepatic index was assayed,serum glutamic-oxalacetic transaminase(GOT) and alkaline phosphatase(ALP) levels and hepatic malondialdehyde(MDA) content were detected,and hepatic pathological examination was also carried out.Results Hepatic index,serum GOT and ALP levels,and hepatic MDA content were increased(P