bc1 - 2 Expresseion in Malignant Melanoma and Melanocytic Nevus / 대한피부과학회지
Korean Journal of Dermatology
;
: 284-291, 1997.
Article
in Korean
| WPRIM
| ID: wpr-57988
ABSTRACT
BACKGROUND:
The bcl-2 is a newly known oncogene involved in tumorigenisis by blocking apoptosis or programmed cell death. Overexpression of bcl-2 protein has been detected in a variety of human malignancies. However, recent studies of the expression of bcl-2 protein in human melanoma and melanocytic nevus have been controversial.OBJECTIVE:
The purpose of this study was to examine whether there are any differences in the expression of bcl-2 protein between melanocytic nevus and rnalignant melanoma.METHODS:
Immunohistochemical analysis of bcl-2 protein expression was performed on the formalin-fixed, paraffin-embedded tissue sections of 22 melanocytic nevus and 29 malignant melanomas (20 primary and 9 metastatic) using anti bcl-2 monoclonal antibody with an avidin-biotin peroxidase complex procedure.RESULTS:
The results were as follows. 1. The positive rate for bcl-2 protein was observed in 95.4% (21/22) of melanocytic nevus and 95.0% (19/20) of primary malignant melanomas. Therefore, there was no significant difference between the two groups in the positive rate for bcl-2 prtoein. 2. The percentage of stained cells and the staining intensity of bcl-2 protein were significantly increased in melanocytic nevus compared to malignant melanoma (p<0.05). 3. The positive rate for bcl-2 expression of metastatic malignant melanoma [44.4% (4/9)] was significantly decreased compared to that of primary malignant melanoma [95.0%(19/20) ] (p<0. 05). But, there was no significant difference betweeen tumor thickness and histological type of malignant, melanoma in the expression of bcl-2 protein. 4. In melanocytic nevus, immunoreactivity of bcl-2 protein gradually diminished or even disappeared towards the deep dermis.CONCLUSION:
the bcl-2 expression was decreased in malignant melanoma compared to melanocytic nevus. It. suggests that the loss of bcl-2 expression may play a significant role in the progression and metastasis of malignant melanoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Cell Death
/
Apoptosis
/
Peroxidase
/
Dermis
/
Melanoma
/
Neoplasm Metastasis
/
Nevus, Pigmented
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
1997
Type:
Article
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