The experimental study of bFGF-fibrin gule-amniotic membrane on corneal alkali burns / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-580135
ABSTRACT
Objective:
To study the effect of a new medical biomaterial—bfgf-fibrin glue-amniotic membrane(bFAM) for corneal alkali burn and provide experimental foundation for the clinical application in the future.Methods:
We use fibrin glue compounded with bFGF and amniotic membrane to prepare the bFAM. 45 New Zealand rabbits were used to make corneal alkali burn models and divided into 3 groupsbFAM group、amniotic membrane group、comparison group, each group have 15 rabbits. After operation, we observe the linical curative effect. 7d、14d and 28d after operation, 5 corneas were extracted for histopathological analysis. The expression of bFGF in corneas was measured by immunohistochemistry analysis.Results:
After operation,bFAM group have better curative effect than amniotic membrane group in Inflammatory reaction、tissue repair and anti-CNV. The expression of bFGF in bFAM group is much higher than amniotic membrane group and comparison group in the day 7 afer operation, and in other time points the expression have not distinct difference in all groups.Conclusion:
Compared with single layer amniotic membrane, bFAM shows better curative effect for corneal alkali burn.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
2007
Type:
Article
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