Chemical constituents in leaves of Acanthopanax gracilistylus / 中草药

ABSTRACT

Objective To study chemical constituents in the leaves of Acanthopanax gracilistylus.Methods The chemical components were isolated and purified by silica gel,ODS C-18,and Sephadex LH-20 column chromatogram.The chemical structures were elucidated on the basis of physicochemical properties and spectral data.Results Seventeen compounds were isolated and identified as(-)-kaur-16-en-19-oic acid(Ⅰ),quercetin(Ⅱ),kaempferol(Ⅲ),protocatechuic acid(Ⅳ),acankoreoside A(Ⅴ),acantrifoside A(Ⅵ),3?,11?-dihydroxy-20(29)-lupene-23,28-dioic acid(Ⅶ),?-sitosterol(Ⅷ),daucosterol(Ⅸ),palmitic acid(Ⅹ),rutin(Ⅺ),stigmast-5,22-dien-3-O-?-D-glucopyranoside(ⅩⅡ),acankoreagenin(ⅩⅢ),3,11-dihydroxy-23-oxo-20(29)-lupen-28-oic acid(ⅩⅣ),3-hydroxy-23-oxo-20(29)-lupen-28-oic acid(ⅩⅤ),myristin(ⅩⅥ),and acanthopanaxgric acid(ⅩⅦ).Conclusion Compounds Ⅱ-Ⅳ,Ⅶ,Ⅺ,ⅩⅡ,ⅩⅣ,and ⅩⅤ are obtained from the leaves of the plant for the first time and compounds ⅩⅦ is a new proved compound named acanthopanaxgric acid.