Impact of the effective parts of Acanthopanax senticosus on GABA,TH and GFAP in C_(57) BL/6 mouse model of parkinson's disease / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-580313
ABSTRACT
AIM:
To study the effect of effective parts of Acanthopanax senticosus on Parkinson's disease mouse model(from C_(57) BL/6 strain) concerning Gammaamino butyric acid(GABA),nigra-striatum tyrosine hydrozylase(TH) and hippocampal glial fibrillary acidic protein(GFAP).METHODS:
In MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropytidine)-induced PD mouse model(accumulative dose amounted to 150 mg/kg) pole-climbing time was determined of mice after receiving effective parts of Acanthopanax senticosus for 20 d,and GARA,TH and GFAP expression were assayed simultaneously with the help of immunohistochemical method.RESULTS:
Mice's pole-climbing time was measured,GABA and TH made a significant difference between treated group and control group(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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