Effects of different anesthetic techniques on circulation,stress response and postoperative recovery in patients undergoing leparoscopic cholecystectomy / 重庆医科大学学报

ABSTRACT

Objective:To investigate the effects of three different anesthetic techniques on pere-anesthesia circulation,stree response and post-anesthesia recovery in patients undergoing leparoscopic cholecystectomy(LC).Methods:Sixty-six ASA Ⅰ or Ⅱ patients aged 18 to 60 undergoing selected LC surgery were randomly divied into 3 groups(n=22).The patients in group I were induced and maintained with remifentanil and sevoflurane.The patients in group Ⅱ with fentanil,propofol and isoflurane,while the patients in group Ⅲ with remifentanil and propofol TCI.MAP and HR were measured before induction,before intubation,at 5 min after intubation,1 min and 15 min after the establishmen of CO2 pneumoperitoneum and at the end of operation.Blood cortisol(Cor)and blood glucose(Glu)were measured before induction,after induction 5 min and at the end of operation;Blood interleukin-6(IL-6)was measured before induction and at the end of operation.Postoperative recovery time,Alddret ≥9,the rate of PONV and VAS score were measured on the first postoperative day.Results:There were significant decreases of MAP in group Ⅰ and Ⅱ before intubation(P 0.05).Conclusion:The three anesthetic techniques can be used safely on LC operation,anesthesia with remifentanil and sevoflurane,anesthesia with remifentanil and propofol TCI have shorter post-operative recovery time and high quality compared with the anesthesia with fentanil,isoflurane and propofol.LC operation can cause obvious stress response of the body,significant postoperative pain and high rate of PONV,which should be actively dealt with.