Expression of epidermal growth factor receptor and cell proliferative protein in thymic carcinoma and type-B3 thymoma / 医学研究生学报

ABSTRACT

Objective:To investigate the expression of epidermal growth factor receptor(EGFR),survivin,P53 protein and proliferating cell nuclear antigen(PCNA) in thymic carcinoma and type-B3 thymoma. Methods:The clinicopathological changes of thymic carcinoma in 9 cases and of type-B3 thymoma(well differentiated thymic carcinoma) in 21 cases were examined by microscopic observation of immunohistochemical stained EGFR,survivin,P53 protein and PCNA,respectively. Results:Clinically,the median age of the patients with the tumor was 43.5 years old.All the tumors displayed a pattern of infiltration growth.Immunohistochemical staining of the tumors indicated that the expressions of EGFR,survivin,P53 protein and PCNA in thymic carcinoma were 77.8%(7/9),88.8%(8/9),77.8%(7/9) and 100%(9/9),respectively.Meanwhile,in type-B3 thymoma,they were 67.7%(14/21),71.4%(15/21),33.3%(7/21) and 85.7%(18/21),respectively.It was statistically significant that the immunohistochemical phenotypes of the tumor displayed a different reaction for P53 protein. Conclusion:The thymic carcinoma and type-B3 thymoma may possess a complete invasive characteristic,clinically.To discriminate thymic carcinoma and type-B3 thymoma,the expression of P53 protein is a more valuable index than EGFR,survivin or PCNA.