Optimization of Wet-shattering Extraction Process of Jingzhi Guanxin Recipe with Uniform Design Method / 中药新药与临床药理

ABSTRACT

Objective To optimize the extraction process of Jingzhi Guanxin Recipe. Methods With the amounts of tanshinone ⅡA,salvianolic acid B,paeoniflorin,ferulic acid and hydroxysafflor yellow A as observation parameters,uniform design method was used for the optimization of wet-shattering extraction process of Jingzhi Guanxin Recipe. Results The optimum extraction process was as followsadding 6-fold 95 %alcohol for the first time of exaction,adding 6-fold 60%alcohol for the second time,adding 6-fold 20 %alcohol for the third time,and shattering for 10 minutes every time. Conclusion This optimized process is efficient,economic and simple.