A comparison of rhPTH(1-34) and calcitonin therapy for post-menopausal women with osteoporosis / 重庆医科大学学报

ABSTRACT

Objective:To observe the therapeutic effects of recombinant human parathyroid hormone[rhPTH(1-34)]and calcitonin on post-menopausal women with osteoporosis.Methods:56 postmenopausal women with osteoporosis were randomly divided in to PTH (n=30)and CT(n=26)groups.The patients in PTH group were treated with rhPTH(1-34)20?g/d by subcutaneous injection,and those in CT group were treated with calcitonin 20 IU/week by intramuscular injection.All patients were given oral calcium(Ca 600 mg+Vit D3 125 U,QD).All the treatments lasted for six months.Lumbar spine(L_(2～4))bone mineral density(BMD),T value,serum calcium,serum phosphate and serum alkline phosphatase were measured in two groups before and after treatment.Results:In two groups BMD was remarkably increased after treatment[PTH(0.74?0.09 vs 0.76?0.08)g/cm~2;CT(0.74?0.09 vs 0.76?0.09)g/cm~2,P