Production of IL-10 and IL-12 by AM and PBMC from lung cancer patients / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-580737
ABSTRACT
Objective:
To investigate the production of IL-10 and IL-12 by alveolar marcrophage and peripheral blood mononuclear cell from lung cancer patients,to evaluate the cellular immune state,and to provide justification for IL-12 therapy in the fields of Lung cancer.Methods:
AM and PBMC were obtained from 57 patients with Lung cancer,33 patients with benign pulmonary disease,and 12 normal control.IL-10 and IL-12 in the culture supernatants were measured quantitatively by ELISA.Results:
(1) Higher levels of IL-10 were found in Lung cancer group than that in NC and BPD group.IL-12 showed significantly lower levels than that in NC and BPD group.(2) The levels of IL-10 had negative correlation with that of IL-12 in Lung cancer group.(3) The levels of IL-10 in Lung cancer group of stage Ⅲ,Ⅳ were significantly higher than that of stage Ⅰ~Ⅱ.The levels of IL-12 in Lung cancer group of stage Ⅳ were significantly lower than that of stage Ⅰ~Ⅱ.(4) Higher levels of IL-10 were found in SCLC group than that in NSCLC group.The levels of IL-12 from PBMC and AM in SCLC group were lower than that in adenocarcinoma,adenocarcinoma and squamous carcinoma groups separately.Conclusion:
(1) results suggest the defect of cell-mediated immunity function presents both in local and general immune response in Lung cancer patients.(2)The basal levels of IL-10 and IL-12 are related to the stage and extent of malignancy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
1986
Type:
Article
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