Pharmacokinetics of oleanolic acid liposomes in rats / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-580819
ABSTRACT
AIM:
To study the pharmacokinetics of oleanolic acid liposomes in rats.METHODS:
Oleanolic acid liposomes were prepared by ethanol injection-sonication;The pharmaceutical properties including morphology,encapsulation efficiency,particle size,zeta potential were determined.Rats were injected with oleanolic acid lipo-somes and oleanolic acid solution via the tail,respectively.The plasma concentrations of sample in rats were assayed by RP-HPLC.The pharmacokinetic parameters were computered by 3P97 program package.RESULTS:
Oleanolic acid liposomes showed almost spherical,the mean diametre was(206.4 ? 4.7) nm.The encapsulation efficiency of oleanolic acid liposomes could be more than 90% based on orthogonal design,and no haemolyticus existed.The plasma concentration-time curves of the oleanolic acid liposomes conformed to a two-compartment model.T1/2? of oleanolic acid liposomes was(33.59 ? 12.53) min,AUC was(240.13 ? 23.62)(?g/mL.min),obviously higher than that of the control preparation.CONCLUSION:
The oleanolic acid liposomes with high entrapment efficiency and even size has a good pharmacokinetic parameters by comparison with non-liposomes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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