Analysis of Utilization and Adverse Drug Reaction of Aminoglycoside Antibiotics in Our Hospital During 2005-2008 / 药物流行病学杂志

ABSTRACT

Objective:To investigate the use and adverse drug reaction of aminoglycoside antibiotics(AmAn) in our hospital during 2005-2008,and to valuate its rationality for reducing its adverse drug reaction.Methods:The data about AmAn's consumption quantity and consumption sum in our hospital were analyzed with the DDD method.Results:Etimicin dominated the first place among AmAn in our hospital,and replaced Gentamicin.The quantities of Netilmicin,Isepamicin and amikacin were stable.In the same period,the main adverse drug reactions were allergic-like reactions,skin rash,ototoxicity and local numbness.Conclusion:Careful selection according to etiology,genetics testing,stronger monitoring of blood concentration and rational dosage treatment will provide a good prospect in the use of AmAn for the multifaceted gram-negative bacteria infection.