The Analysis Method of Self-emulsifying Drug Delivery System in Curcumin by HPLC / 中国中医药信息杂志

ABSTRACT

Objective To establish the HPLC method for determination of self-emulsifying drug delivery system in Curcumin. Method Kromasil ODS C18 (150 mm?4.6 mm, 5 ?m) was used. The mobile phase was methanol-water (0.5% acetic acid glacial)(70∶30). The detection wavelength was set at 428 nm. The flow rate was 0.9 mL/min, with temperature of 32 ℃. Result The linear range of Curcumin was 4.5～112.5 ?g/mL, r=0.999 9. Conclusion This method was simple and accurate. It can be used for the determination of self-emulsifying drug delivery system in Curcumin.