Immunomodulatory Function of Antibiotics and Their Effects on Pulmonary Fibrosis / 航天医学与医学工程
Space Medicine & Medical Engineering
;
(6)2006.
Article
in Chinese
| WPRIM
| ID: wpr-581041
ABSTRACT
Objective To study the immuno-regulatory roles of antibiotics and their implication for pulmonary fibrosis.Methods The regulatory roles of antibiotics on the phenotypes of dendrite cells(DCs) and maturation of B lymphocytes in vitro were detected with flow cytometry.The roles of nystatin on pulmonary fibrosis in vivo were determined with bleomycin-induced acute injury model of mouse.Results Multiple antibiotics including nystatin apparently promoted the maturation of DCs and B cells,as well as subsequently promoted the polarization of Th2 cells through DCs.In addition,nystatin intensified bleomycin-induced pulmonary fibrosis.Conclusion Multiple antibiotics including nystatin induce suppressive immune responses and might aggravate pulmonary fibrosis like nystatin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Space Medicine & Medical Engineering
Year:
2006
Type:
Article
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