Optimization of total epimediumon flavone microporosity osmotic pump tablet formulation by box-behnken design and response surface methodology / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-581162
ABSTRACT
AIM:
To optimize total flavone of herba epimediumon microporosity osmotic pump tablets by boxbehnken design-response surface methodology.METHODS:
Osmotic agent (lactose),dosage of plastificator (dibutyl phthalate),and coating weight gain were selected as key factors of influencing total flavone delivery. Total flavones cumulatiive yield in 12 h and fitting approximation was regarded as the response. Design Expert method useful for the modeling and analysis was to optimize the response.RESULTS:
Response surface surface obtained repre-sented maximum one which conformed to the zero-order delivery rate equation.CONCLUSION:
Optimal excipient formulation of total epimedium flavone microporosity osmotic pump tablet consists of 0. 18 g of lactose,0. 26 ratio of dibutyl phthalate to acetyl celulose and 7. 7% of coating weight gain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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