The clinical significance of p16~(INK4a) in cervical cytology staging / 重庆医科大学学报

ABSTRACT

Objective:To investigate the expression and significance ofp16INK4a and HPV16/18 in atypical squamous cells of undetermined significance(ASC-US),atypical squamous cells,cannot exclude high-grade squamous intraepithelial lesion(ASC-H),low-grade squamous intraepithelial lesion(LSIL),high-grade squamous intraepithelial lesion(HSIL).Methods:p16INK4a and HPV16/18 DNA in thin-layer slides from 89 specimens were detected by immunohistochemistry and the insitu hybridization.Results:A positive correlation was found between the positive rate of p16INK4a and cervical disease progression,the positive rate of p16INK4a in LSIL,HSIL,ASC-H were higher than ASC-US(P