Comparison of transforming growth factor-?_1 expression and therapeutic effects on tibia and fibular fracture with two different fixation methods / 重庆医科大学学报

ABSTRACT

Objective:To detect the expression of TGF-?1 in tibia and fibula fracture with two methods of compression plate fixation and intramedullary nail fixation,and to evaluate their therapeutic effects.Methods:117 patients with non severe tibia and fibula fractures were separated into two groups.One group received pressurized plates fixation for treatment,the other received intramedullary nail fixation.On 1,7,30 and 90 days after surgery,TGF-?1 was detected by ELISA,and on 30 days after surgery the clinical efficacy were also assessed. Results:The TGF-?1 content increased on 7 days as compared with that on 1 days after surgery,and the TGF-?1 content gradually decreased at on 30 to 90 days after surgery.The TGF-?1 content in compression plate fixation group were lower than that in intramedullary nailing group every points of four days(P