Effects of Blood Transfusion and Cyclophosphamide on the Bone Marrow Transplantation in Rats with Lethal ?-irradiation / 中国输血杂志

ABSTRACT

Therapeutic effects of blood transfusion and cyclophosphamide (CY) on the bone marrow transplantation (BMT) in rats with lethal ?-irradiation were studied. The results of 60-day after irradiation in each experimental group were as follows: The survival rates in the group only treated with BMT were 55%. In the groups with blood transfusion five days before and one day after BMT, the survival rates were 0% and 30% respectively. The survival rates of the group with blood transfusion one day before BMT increased to 90%, but when administration of CY was added the therapeutic effect decreased markedly. The cells of the donor type in the rats survived more than 10 and 100 days. The results showed that the therapeutic effect of BMT in the lethal irradiation was strongly related to the time of blood transfusion, and the additional administration of CY decreased the therapeutic effect.