Effect of islet amyloid polypeptide(Amylin) on glucose metabolism and secretion of insulin in the rats / 中国糖尿病杂志

ABSTRACT

The effect of continuous amylin infusion on glucose tolerance in rats and the effect of amylin on glucose-stimulated insulin secretion from isolated rat pancreatic islets were sudied. Three groups of animals formed the study of glucose tolerance Group 1 received salined infusion; Group2 , amylin at 2. 6 nmol?kg-1/h;and group 3,amylin at 26 nmol**kg-1/h. The total infusion time was 60 min. The insulin level and serum glucose were not altered at lower dose of amylin. However glucose levels markedly rose at 2.7,12 min. after beginning IVGTT, without significant change of insulin levels in group 3. The response of insulin to 16. 7 mol glucose-stimulated isolated rat pancretic islets was singnificantly inhibiled by the addition of amylin 10 umol.