STUDIES ON TOTAL SYNTHESIS AND STRUCTURE——ACTIVITY RELATIONSHIP OF MARINE ALGA ANTIBIOTIC( - ) -MALYNGOLID IV synthesis of 5 - hydroxymethyl - 5 - benzyl - s -valerolactone / 中国海洋药物

ABSTRACT

Title compund have been synthesized from adipic acid (starting material ) in six steps, a chiral phase transfer catalyst (3s,4s)-1-benzyle-1-methyl-3,4 - pyrrolidindiol-onium iodide (PTC) was used to promote the iasymmetric reactions in the key steps of forming chiral centers