Preliminary Investigation on MHC-Nonrestricted Tumorlytic Effect Mediated by CD3AK / 中国肿瘤生物治疗杂志

ABSTRACT

The result showed that CD3AK induced and expanded in vitro could kill MHC I class - negative K562 (NK - sensitive) and Daudi (NK - resistant) tumor cells in a MHC - nonrestricted manner. Induction of necrosis and / or apoptosis of target cells were responsible for the tumorlytic effect mediated by CD3AK.