EFFECT OF CHITOSAN ON DELAYED OUTWARD POTASSIUM CURRENT IN SINGLE VENTRICULAR MYOCYTES OF GUINEA PIG / 中国海洋药物

ABSTRACT

To study the effect of chitosan on delayed outward potassium current(IK) in single ventricular myocytes of guinea pig and investigate its antiarrhythmic mechanism from ion channel view. Patch clamp technique with whole-cell configuration. Holding potential was -40mV,commanding potential was -60- + 70mV ,step pulse +10mV,stimulating frequency 1 Hz,duration 300 ms and stimulating interval 6s. The result showed that Chitosan inhibited IK in a dose -dependent manner. Conclusion:Chitosan can inhibite IK in single ventricular myocytes of guinea pig.