Influence of metformin on the protein expression of IRS-1 in target tissues or OLETF rats / 中国糖尿病杂志
Chinese Journal of Diabetes
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-581992
ABSTRACT
Objective To investigate the molecular mechanism of metformin. Methods The changes of protein expression of IRS-1 in liver, skeletal muscle and adipose tissues after treatment with metformin for OLETF rats, a model of spontaneous type 2 diabetes mellitus, were measured by Western blot analysis, and compared with those before treatment. Results 22 weeks after the treatment with metformin, the protein expression of IRS-1 was significantly increased in liver (P0. 05) ;and the protein expression of IRS-1 in adipose tissue was significantly decreased (P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Diabetes
Year:
2000
Type:
Article
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