The influence of polysaaccharide from Spirulina platensis on human embryo lung diploid fibroblastic DNA damage and repair after UV irradiation / 中国海洋药物

ABSTRACT

Objective To observe the influence of polysaccharide from spirulina platensis(PSP) on human embryo lung diploid fibroblastic DNA damage and repair after UV irradiation. Methods After UV irradiation for 30min, the single cell gel electrophoresis(SCGE) was used to investigate the level of DNA damage, the level of DNA damage and repair at 30, 60, 90min were also investigated by SCGE respectively. Results The level of DNA damage induced by UV irradiation was prevented by PSP, and it also promote DNA repair capacity. Conclusion PSP can increase the activity of DNA endonuclease and DNA ligase in dose-de- pendrntly.