Therapeutic role on monoclonal antibody of alkaline phosphatase to vasogenic cerebral edema in rats / 临床神经病学杂志
Journal of Clinical Neurology
; (6)1995.
Article
in Zh
| WPRIM
| ID: wpr-582217
Responsible library:
WPRO
ABSTRACT
Objective To observe the therapeutic role on monoclonal antibody of alkaline phosphatase(AAP) to vasogenic cerebral edema in rats(VCE).Methods 60 Wistar rats were randomly divided into 3 groups:normal group,VCE group and AAP group.VCE animal model was made by injecting AAP.Brain water content of gray and white matter were measured by Moistrue Analyzer respectively.The permeability of the blood brain barrier (BBB) was determined by Evan's blue(EB) extravasation.Results The brain water content of gray and white matter in AAP group was reduced markedly,so the permeability of BBB was reduced(P0.05). Conclusion AAP can treat VCE well. Morbidity mechanism of VCE is related to the activity of alkaline phosphatase.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Journal of Clinical Neurology
Year:
1995
Type:
Article