The association study between peroxisome proliferator-activated receptor ?2 gene polymorphism and type 2 diabetes mellitus / 中国糖尿病杂志

ABSTRACT

Objective To study the association of peroxisome proliferator activated receptor?2 (PPAR?2) gene polymorphism with type 2 diabetes mellitus.Methods PPAR?2 gene Pro12Ala polymorphism was examined using polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) in 101 couples of type 2 diabetes mellitus normal control.Results In control group, heterozygosity carriers had lower serum apolipoprotein B (P=0 006).The Pro12Ala polymorphism in PPAR?2 gene is not associated with type 2 diabetes mellitus(OR=1.48,95%CI=0.52～4.18,P=0.461).Conclusion PPAR?2 gene Pro12Ala polymorphism is associated with abnormal lipid metabolism; PPAR?2 gene may not play a critical role in the development of type 2 diabetes mellitus in Han of Beijing Chinese.