A study on the chitosan-tripolyphosphate sodium complex matrix Pellets / 中国海洋药物

ABSTRACT

VE Chitosan and sodium tripolyphosphate were used as Complex matrix material for preparing pellets loading sodium diclofenac and its properties were studied. METHODS Chitosantripolyphosphate sodium polyelectrolyte was prepared according to the principle of static electricity polymerization. Its properties and structure characteristics were further investigated. The preparation process, effective factors and the optimal condition for the pellets loading sodium diclofenac were studied. RESULTS IR indicated that the structure of compound contained -NH3+-O-P group. DTA demonstrated that polyelectrolyte had an exothermic peak. There was no interaction between the drug and expedient. SEM showed that the surface of the pellets was regular, dense and the structure of the surface wasn't consistent with the inner. The pellets prepared by this method were uniform, round, well-distributed, hardy, good-mobility and its average diameter was about 10mm. CONCLUSION Chitosan-tripolyphosphate sodium polyelectrolyte could be used as a good matrix material for preparing pellets.