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Infections after lung transplantation: time of occurrence, sites, and microbiologic etiologies
The Korean Journal of Internal Medicine ; : 506-514, 2015.
Article in English | WPRIM | ID: wpr-58265
ABSTRACT
BACKGROUND/

AIMS:

Infections are major causes of both early and late death after lung transplantation (LT). The development of prophylaxis strategies has altered the epidemiology of post-LT infections; however, recent epidemiological data are limited. We evaluated infections after LT at our institution by time of occurrence, site of infections, and microbiologic etiologies.

METHODS:

All consecutive patients undergoing lung or heart-lung transplantation between October 2008 and August 2014 at our institution were enrolled. Cases of infections after LT were initially identified from the prospective registry database, which was followed by a detailed review of the patients' medical records.

RESULTS:

A total of 108 episodes of post-LT infections (56 bacterial, 43 viral, and nine fungal infections) were observed in 34 LT recipients. Within 1 month after LT, the most common bacterial infections were catheter-related bloodstream infections (42%). Pneumonia was the most common site of bacterial infection in the 2- to 6-month period (28%) and after 6 months (47%). Cytomegalovirus was the most common viral infection within 1 month (75%) and in the 2- to 6-month period (80%). Respiratory viruses were the most common viruses after 6 months (48%). Catheter-related candidemia was the most common fungal infection. Invasive pulmonary aspergillosis developed after 6 months. Survival rates at the first and third years were 79% and 73%, respectively.

CONCLUSIONS:

Although this study was performed in a single center, we provide valuable and recent detailed epidemiology data for post-LT infections. A further multicenter study is required to properly evaluate the epidemiology of post-LT infections in Korea.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Bacterial Infections / Virus Diseases / Registries / Medical Records / Risk Factors / Heart-Lung Transplantation / Lung Transplantation / Treatment Outcome / Cytomegalovirus Infections Type of study: Controlled clinical trial / Etiology study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: The Korean Journal of Internal Medicine Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Bacterial Infections / Virus Diseases / Registries / Medical Records / Risk Factors / Heart-Lung Transplantation / Lung Transplantation / Treatment Outcome / Cytomegalovirus Infections Type of study: Controlled clinical trial / Etiology study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: The Korean Journal of Internal Medicine Year: 2015 Type: Article