Infections after lung transplantation: time of occurrence, sites, and microbiologic etiologies
The Korean Journal of Internal Medicine
;
: 506-514, 2015.
Article
in English
| WPRIM
| ID: wpr-58265
ABSTRACT
BACKGROUND/AIMS:
Infections are major causes of both early and late death after lung transplantation (LT). The development of prophylaxis strategies has altered the epidemiology of post-LT infections; however, recent epidemiological data are limited. We evaluated infections after LT at our institution by time of occurrence, site of infections, and microbiologic etiologies.METHODS:
All consecutive patients undergoing lung or heart-lung transplantation between October 2008 and August 2014 at our institution were enrolled. Cases of infections after LT were initially identified from the prospective registry database, which was followed by a detailed review of the patients' medical records.RESULTS:
A total of 108 episodes of post-LT infections (56 bacterial, 43 viral, and nine fungal infections) were observed in 34 LT recipients. Within 1 month after LT, the most common bacterial infections were catheter-related bloodstream infections (42%). Pneumonia was the most common site of bacterial infection in the 2- to 6-month period (28%) and after 6 months (47%). Cytomegalovirus was the most common viral infection within 1 month (75%) and in the 2- to 6-month period (80%). Respiratory viruses were the most common viruses after 6 months (48%). Catheter-related candidemia was the most common fungal infection. Invasive pulmonary aspergillosis developed after 6 months. Survival rates at the first and third years were 79% and 73%, respectively.CONCLUSIONS:
Although this study was performed in a single center, we provide valuable and recent detailed epidemiology data for post-LT infections. A further multicenter study is required to properly evaluate the epidemiology of post-LT infections in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Time Factors
/
Bacterial Infections
/
Virus Diseases
/
Registries
/
Medical Records
/
Risk Factors
/
Heart-Lung Transplantation
/
Lung Transplantation
/
Treatment Outcome
/
Cytomegalovirus Infections
Type of study:
Controlled clinical trial
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS