Clinical significance of breast cancer resistance protein mRNA in patients with cervical cancer / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 754-755,762, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-582946
ABSTRACT
Objective To investigate the mRNA expression of breast cancer resistance protein (BCRP) in cervical cancer (CC).Methods The expression of BCRP mRNA was detected by real-time PCR from tissues of 12 normal and 47 cases with CC.Results The expression of BCRP mRNA was 0.59±0.26 in CC and 0.19±0.17 in normal cervical tissues.But it was significantly higher in CC than those in normal tissues (P < 0.05).The expression of BCRP mRNA was not correlated with histological types,tumor differentiation degree and clinical stages (P > 0.05).Conclusion BCRP mRNA over-expresses in CC,wich might play a major role in the intrinsic MDR of CC.Detection of BCRP mRNA expression may the guidance of individualized chemotherapy for patients with CC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Practice guideline
Language:
Chinese
Journal:
Cancer Research and Clinic
Year:
2013
Type:
Article
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