The effectiveness of natri valproate in treatment of 238 children with grand mal seizure epilepsy at Hai Phong children hospital

ABSTRACT

Background:Seizure epilepsy is a social disease and appear at all age in most of countries. The rate of seizure epilepsy is increasing account for 10% of all cases.Objectives:This study aims to learn about the effectiveness of natri valproate in treatment of 238 children with grand mal seizure epilepsy at Hai Phong children hospital. Subjects and method: A retrospective and prospective study was conducted on 238 children with grandmal seizure epilepsy treated by natri valproate at Hai Phong Children Hospital from December 2005 to April 2007. Results:A complete remission rate was 87.8%, uncompleted remission in 10.1 % and non - responsive in 2.1 % after 15 days of treatment. After 6 months of treatment, a complete remission was seen in 92.5%, uncompleted remission in 6.1 % and non - responsive in 1.4% The electrocardiogram (ECG) showed paroxystic electric discharge in 71.9% of patients before treatment and in 32.1 % after treatment. Conclusion: In general, natri valproate was well tolerated in children. However, there were some complications and side effects such as somnolence and fatigue (23.6%), digestive disorder (5.7%), weight increase (4.7%), alopecia (2.8%), tremor (1.4%) but these complications and side effects were frequently mild and can be controlled.