Bone regeneration of the fluoridated hydroxyapatite and the bio-glass in the rabbit cranium defect model
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 380-385, 2011.
Article
in Korean
| WPRIM
| ID: wpr-58316
ABSTRACT
INTRODUCTION:
Hydroxyapatite (Ca10(PO4)6(OH)2, HA) is the main inorganic phase of human hard tissue that is used widely as the repair material for bones. When HA is applied to a bony defect, however, it can be encapsulated with fibrous tissue and float in the implanted area due to a lack of consolidation. Bioceramics as allogenic graft materials are added to HA to improve the rate and bone healing capacity. Fluoridated hydroxyapatite (Ca10(PO4)6(OH,F)2, FHA), where F- partially replaces the OH- in hydroxyapatite, is considered a good alternative material for bone repair owing to its solubility and biocompatibility. MATERIALS ANDMETHODS:
This study was designed to determine the bone healing capacity of FHA newly produced as a nanoscale fiber in the laboratory. HA and FHA with bioglass was implanted in a rabbit cranium defect and the specimen was analysed histologically.RESULTS:
1. At 4 weeks, fibrous connective tissue and little bone formation was observed around the materials of the experimental group I implanted HA and bioglass. Newly formed bone was observed around the materials in the experimental group II implanted FHA and bioglass. 2. At 8 weeks, the amount of newly formed and matured bone was higher in experimental group II than in experimental group I and the control group.CONCLUSION:
These results suggest that FHA and bioglass is a relatively favorable bone substitute with biocompatibility and better bone healing capacity than pure HA and bioglass.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Skull
/
Solubility
/
Acrylic Resins
/
Bone Regeneration
/
Ceramics
/
Durapatite
/
Bone Substitutes
/
Connective Tissue
/
Transplants
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2011
Type:
Article
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