Restoration of endothelial function after reperfusio injury by tetrahydrobiopterin / 中国介入心脏病学杂志

ABSTRACT

Objective To evaluate the influence of tetrahydrobiopterin on NO and MDA concentration and SOD activity as well as the myocardial infarction area. Methods Twenty-four rabbits were divided into three groups randomly control group,MI/R group and BH 4 group. After occlusion of the left anterior descending coronary artery of a rabbit for 60 minutes followed by 90 minutes of reperfusion (ischemia/reperfusion),NO and MDA and SOD concentrations were measured and the myocardial infarction area was caculated. Results Compared with control group,the NO concentration in MI/R group was markedly decreased [(28?10) ?mol/L vs (116?17) ?mol/L,P 0.05];There was significant difference between MI/R and BH 4 groups in infarction area,too. [(18?4)% vs (16?4)%,P