Research on the hemostasis effect of chitos an's structure / 医疗卫生装备

ABSTRACT

The effects of chitosan and N,O-carboxymethyl chitosan on blood hemostasis are tested.The dynamic blood coagulation experiments show chitsan with low deacetylation degree has higher absorption ability.The experiments can't find that any altered red blood cell morphology or an unusual affinity between erythrocytes appears evidently in the ACD blood treated with chitosan.The concentration of the platelets on the chitosan surface may be one of causes that platelets produce blood coagulation.Chitosan is substituted by the carboxymethyl and has water solubility.But N,O-carboxymethyl chitosan can lead torouleau and not toaltering the morphology of the erythrocyte.The blood hemostasis effect is not obvious.The values of TT,PT,APTT and FIB are measured from blood and the results fail toprove that chitosan and N,O-carboxymethyl chitosan can activate the coagulation factors.