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The Antitumor Effects of Tumor Vaccine with Expression of Granulocyte-Macrophage Colony-Stimulating Factor Anchored on Mouse Melanoma Tumor Cell Surface / 中国肿瘤生物治疗杂志
Chinese Journal of Cancer Biotherapy ; (6)1994.
Article in Chinese | WPRIM | ID: wpr-583627
ABSTRACT

Objective:

To investigate the vaccine potency of GM-CSF anchored B16 tumor cells.

Methods:

In this study, mGM-CSF was expressed on surface of B16 mice melanoma cells by GPI-modifying. C57BL/6 mice were inoculated with GM-CSF anchored cells and wide-type B16 cells to evaluate whether the GM-CSF anchored cells could elicit a protective and systemtic antitumor response.

Results:

GM-CSF anchored cells resulted in remarkable loss of tumorgenicity in syngenetic mice. The tumor occurrence rate of GM-CSF anchored B16 cells was 58. 8% on C57BL/6 mice with 1 ? 106 B16 cells/mice inoculated ( n = 12) and that of wide-type B16 cells was 100% , The C57BL/6 mice receiving inoculation with 5 ? 105GM-CSF anchored cells/mice never grew tumor. These mice were challenged with wide-type B16 cells, and only a minority of mice grew tumor after wide-type B16 cells inoculation.

Conclusion:

GM-CSF protein anchored cells could elicit a protective and systemtic antitumor responses.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Cancer Biotherapy Year: 1994 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Cancer Biotherapy Year: 1994 Type: Article