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Effects of thrombolytic therapy combined with dextran sulfate in rat with cerebral embolism / 临床神经病学杂志
Article in Chinese | WPRIM | ID: wpr-583694
Responsible library: WPRO
ABSTRACT
Objective To study the effect of dextran sulfate inhibiting leukocytes infiltration and infarct size,and apoptosis in rats with cerebral embolism.Methods Using one's blood emboli,dextran sulfate (4 mg/kg) or saline was intravenously administered after half an hour ischemia and urokinase (5000 U/kg) was injected after 2h or 4h ischemia in rat embolic stroke models.At 12h or 24h after ischemia,the infarct size were measured by TTC staining.ICAM-1 expression and leukocytes infiltration were evaluated by immunohistochemistry, apoptosis were detected by TUNEL;blood-brain barrier(BBB) and cell necrosis were observed by electromicroscopy.Results combined thrombolytic group compared with pure thrombolytic group,the infarct focus decreased(P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Clinical Neurology Year: 1988 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Clinical Neurology Year: 1988 Type: Article