A Metastatic Granulocyte Colony-Stimulating Factor Producing Sarcomatoid Carcinoma of the Lung Causing Jejunal Intussusception: Report of a Case
Korean Journal of Pathology
;
: 205-208, 2011.
Article
in English
| WPRIM
| ID: wpr-58374
ABSTRACT
A 75-year-old man was referred to our hospital with intestinal obstruction caused by intussusception. Abdominal computed tomography (CT) revealed seven polypoid masses in the small intestine, while chest CT revealed a mass in the right lower lobe. Preoperative laboratory tests showed white blood cell (WBC) and neutrophil differential counts of 63,630/mm3 and 95%, respectively. The serum granulocyte colony-stimulating factor (G-CSF) was 114 pg/mL, which was elevated (normal range, <18.1 pg/mL). After resection of the small bowel, the WBC count decreased to 20,510/mm3. The pathology showed a poorly differentiated carcinoma with sarcomatous components confirmed by positive immunostaining of cytokeratin (AE1/AE3) and vimentin in the small intestine. Furthermore, immunohistochemistry with specific monoclonal antibodies against G-CSF was positive. A lung biopsy revealed the same histological findings as the small intestine lesion. Therefore, the patient was diagnosed as having a G-CSF producing sarcomatoid carcinoma of the lung with metastasis to the small intestine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thorax
/
Vimentin
/
Biopsy
/
Immunohistochemistry
/
Carcinosarcoma
/
Granulocyte Colony-Stimulating Factor
/
Granulocytes
/
Intestinal Obstruction
/
Intestine, Small
/
Intussusception
Limits:
Aged
/
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2011
Type:
Article
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