Effects of CO_2 pneumoperitoneum on pulmonary functions in rabbits with chronic pulmonary failure:An experimental study / 中国微创外科杂志

ABSTRACT

Objective To investigate the effects of CO 2 pneumoperitoneum during laparoscopic cholecystectomy (LC) on pulmonary functions in chronic pulmonary failure rabbits and their mechanisms. Methods A total of 50 healthy male rabbits ( oryctolagus cuniculus ) were randomly divided into 4 groups normal control group (N 0 n=5, no pneumoperitoneum), experimental control group (T 0 n=5, no pneumoperitoneum), 10 mmHg experimental group (T 10 n=20, 10 mmHg pneumoperitoneum) and 15 mmHg experimental group (T 15 n=20, 15 mmHg pneumoperitoneum). After the successful establishment of emphysema rabbit models, CO 2 pneumoperitoneum was conducted and maintained for 2 hours at the pressure of 10 mmHg (1.33 kPa) and 15 mmHg (2.00 kPa), respectively. Pulmonary functions (total respiratory resistance, central resistance and total airway resistance) of the 4 groups were measured by pulse oscillation technique before and after the pneumoperitoneum, respectively. Results Total respiratory resistance, central resistance and total airway resistance increased after the establishment of emphysema models. And they decreased at the end of pneumoperitoneum compared with those before pneumoperitoneum ( q=17.824, P